Recent Research Publications

 2010: 

Bimonte-Nelson H.A., Acosta J.I., Talboom J.S. (2010) Neuroscientists as cartographers: mapping the crossroads of gonadal hormones, memory and age using animal models, Molecules, 15(9), 6050-105. psychology.clas.asu.edu/files/Bimonte-Nelson2010MoleculesReview.pdf

Braden B.B., Talboom J., Crain I., Simard, A., Lukas, R., Prokai L., Scheldrup M., Bowman, B., Bimonte-Nelson H.A. (2010) Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats, Neurobiology of Learning and Memory 93(3), 444-53. psychology.clas.asu.edu/files/BradenNBLM2010.pdf

Conrad, Cheryl D., & Bimonte-Nelson, Heather A. (2010) Impact of the hypothalamic-pituitary-adrenal/gonadal axes on trajectory of age-related cognitive decline, In: Progress in Brain Research, 182, Neuroendocrinology: Pathological Situations and Diseases, (pages 31-76). Edited by: Martini, Luciano, Chrousos, George P., Labrie, Fernand, Pacak, Karel, & Pfaff, Donald W., Elsevier Publications New York, NY.  

Talboom J.S., Engler-Chiurazzi E.B., Whiteaker P., Simard A.R., Lukas R., Acosta J.I., Prokai L., Bimonte-Nelson H.A. (2010) A component of Premarin(®) enhances multiple cognitive functions and influences nicotinic receptor expression, Hormones and Behavior, 58, 917-928psychology.clas.asu.edu/files/TalboomNBLM2010.pdf

Engler-Chiurazzi E., Tsang C., Nonnenmacher S., Liang W., Corneveaux J., Prokai L., Huentelman M., and Bimonte-Nelson H.A. Tonic Premarin dose-dependently enhances memory, affects neurotrophin protein and alters gene expression in middle-aged rats, Neurobiology of Aging, in press. psychology.clas.asu.edu/files/EnglerNBA2009.pdf 

Lockrow J, Boger H, Bimonte-Nelson H.A., Granholm AC. Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome, Behavioral Brain Research, in press. psychology.clas.asu.edu/files/memantine paper2010.pdf

2009:

Acosta J.I., Mayer L., Talboom J.S., Tsang C., Smith C., Enders C., Bimonte-Nelson H.A. (2009) Transitional versus surgical menopause in a rodent model: etiology of ovarian hormone loss impacts memory and the acetylcholine system, Endocrinology, 150 (9) 4248-4259. psychology.clas.asu.edu/files/AcostaEndocrin2009VCD.pdf

Acosta J., Mayer L., Talboom J.S., Zay C.A., Scheldrup M., Castillo J., Demers L., Enders C., Bimonte-Nelson H.A. (2009) Premarin improves memory, prevents scopolamine-induced amnesia and increases number of basal forebrain choline acetyltransferase positive cells in middle-aged surgically menopausal rats, Hormones and Behavior, 55, 454–464. psychology.clas.asu.edu/files/AcostaHorBehPremarin2009.pdf

Sas A., Bimonte-Nelson H.A., Smothers C., Woodward J., Tyor W. (2009) Interferon alpha causes neuronal dysfunction in encephalitis, Journal of Neuroscience, 29(12), 3948-55. psychology.clas.asu.edu/files/Sas2009.pdf 

Lockrow J, Prakasam A, Huang P, Bimonte-Nelson H.A., Sambamurti K, Granholm AC. (2009) Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model, Experimental Neurology, 216(2), 278-89psychology.clas.asu.edu/files/LockrowVitE2009.pdf

Huentelman M.J., Stephan D.A., Talboom J.S., Reiman D.M., Gerber J.D., Barnes C.A., Alexander G.E., Reiman E.M., Bimonte-Nelson H.A. (2009) Peripheral delivery of a ROCK inhibitor improves learning and working memory, Behavioral Neuroscience, 123(1), 218-223. psychology.clas.asu.edu/files/huentelmanBehNeuro.pdf

2008:

Rao V.R., Sas A., Eugenin E., Siddappa N.B., Bimonte-Nelson H.A., Berman J., Ranga U., Tyor W.R., and Prasad V.R. (2008) HIV-1 clade-specific differences in the induction of neuropathogenesis, Journal of Neuroscience, 28(40):10010-10016. psychology.clas.asu.edu/files/RaoJNeuroscienceHIV.pdf

Mclaughlin, K. Bimonte-Nelson, H., Neisewander, J., Conrad, C. (2008) Assessment of estradiol influence on spatial tasks and hippocampal CA1 spines: Evidence that prolonged ovariectomy compromises 17 beta-estradiol effectiveness in altering CA1 spines, Hormones and Behavior, 54(3), 386-395. psychology.clas.asu.edu/files/MaclaughlinHormBeh2008.pdf

Thirumangalakudi L., Prakasam A., Zhang R., Bimonte-Nelson H.A., Sambamurti K., Kindy M. and Bhat N. (2008) High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice, Journal of Neurochemistry, 106(1), 475-485. psychology.clas.asu.edu/files/ThirumangalJofNeurochem.pdf

Granholm A-Ch., Bimonte-Nelson H.A., Moore A.B., Nelson M., Freeman L.R, Sambamurti K. (2008) Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat, Journal of Alzheimer’s Disease, 14(2),133-145. psychology.clas.asu.edu/files/GranholmetalJAD2--8.pdf

Talboom J.S., Williams B.J., Baxley E., West, S., Bimonte-Nelson H.A. (2008) Higher levels of estradiol correlate with better spatial memory in surgically menopausal young and middle-aged rats, Neurobiology of Learning and Memory, 90, 155-163. psychology.clas.asu.edu/files/TalboomNBLM2008Eage.pdf

2007:

Bimonte-Nelson H.A., Granholm, A.C, Nelson, M.E., Moore, A.B. (2008) Patterns of neurotrophin protein levels in male and female rats from adulthood to senescence, Experimental Aging Research, 4, 13-26. psychology.clas.asu.edu/files/Bim-NelsonExpAgingRes2008.pdf 

Sas A., Bimonte-Nelson H.A., Tyor WR. (2007) Cognitive dysfunction in HIV encephalitic SCID mice correlates with levels of Interferon-alpha in the brain, AIDS, 21, 2151-9. psychology.clas.asu.edu/files/SasAIDS2007.pdf  

French, K.L., Bimonte-Nelson, HA, Granholm, A-Ch. (2007) Galantamine effects on memory, spatial cue utilization and neurotrophic factors in aged female rats, Cell Transplantation, Special Aging Issue, 16, 197-205. psychology.clas.asu.edu/files/FrenchCellTransplantation2007.pdf

2006:

Williams BJ, Bimonte-Nelson HA and Granholm-Bentley AC. (2006) ERK-mediated NGF signaling in the rat septo-hippocampal pathway diminishes with age, Psychopharmacology, 88, 605-618. psychology.clas.asu.edu/files/WilliamsPsychopharm2006.pdf

French KL, Granholm AC, Moore AB, Nelson ME, Bimonte-Nelson HA (2006) Chronic nicotine mproves working and reference memory performance and reduces hippocampal NGF in aged female rats. Behavioral Brain Research, 169, 256-262. psychology.clas.asu.edu/files/FrenchBehBrainRes2006.pdf

Bimonte-Nelson, HA, Francis, K.R., Umphlet, C.D. and Granholm, A-C. (2006) Progesterone reverses the spatial memory enhancements of tonic and cyclic estrogen therapy in middle-aged female rats. European Journal of Neuroscience, 24, 229-242. psychology.clas.asu.edu/files/Bim-NelsonEJN2006.pdf

2004:

Hunter CL, Bimonte-Nelson HA, Nelson M, Eckman CB, Granholm AC. (2004) Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiology of Aging, 25, 873-84. psychology.clas.asu.edu/files/HunterNBA2004.pdf 

Bimonte-Nelson, H.A., Singleton, R.S., Williams, B.J., and Granholm, A.C. (2004) Ovarian hormones and cognition in the aged female rat: II. Progesterone supplementation reverses the cognitive enhancing effects of ovariectomy. Behavioral Neuroscience, 118, 707-714. psychology.clas.asu.edu/files/Bim-NelsonBehNeuro2004.pdf 

Bimonte-Nelson, H.A., Nelson, M.E, and Granholm, A.C. (2004) Progesterone counteracts estrogen-induced increases in neurotrophins in the aged female rat brain, Neuroreport, 15, 2659-2663. psychology.clas.asu.edu/files/Bim-NelsonNeuroreport2004.pdf

2003:

Bimonte, H.A., Nelson, M.E., and Granholm, A.C. (2003) Age-related deficits as working memory load increases: relationships with growth factors. Neurobiology of Aging, 24, 37-48. psychology.clas.asu.edu/files/BimonteNBA2003.pdf

Bimonte, H.A., Hunter, C.L., Nelson, M.E., and Granholm, A-C. (2003) Frontal cortex BDNF levels correlate with working memory in an animal model of Down Syndrome. Behavioural Brain Research, 139, 47-57. psychology.clas.asu.edu/files/Bim-NelsonBehBrainRes2003.pdf

Hunter, C.L., Bimonte, H.A., and Granholm, A-C. (2003) Behavioral comparison of four and six month-old Ts65Dn mice: age-related impairments in working and reference memory. Behavioural Brain Research, 138, 121-131. psychology.clas.asu.edu/files/HunterBehBrainRes2003.pdf 

Hunter, C.L., Isacson, O., Nelson, M., Bimonte-Nelson, H.A., Seo., H., Lin, L., Ford, K., Kindy, M., and Granholm, A-C. (2003) Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down’s Syndrome. Neuroscience Research, 45(4):437-45. psychology.clas.asu.edu/files/HunterNeurRes2003.pdf 

Bimonte-Nelson, H.A., Singleton, R.S., Nelson, M.E., Eckman, C.B., Barber, J., Scott, T.Y., and Granholm, A.C. (2003) Testosterone, but not non-aromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats. Experimental Neurology, 81(2):301-12. psychology.clas.asu.edu/files/Bim-NelsonExpNeuro2003.pdf

Bimonte-Nelson, H.A., Singleton, R.S., Hunter, C.L., Price, K.L., Moore, A., and Granholm, A.-C. (2003) Ovarian hormones and cognition in the aged female rat: I. Long-term, but not short-term, ovariectomy enhances spatial performance. Behavioral Neuroscience, 117, 1395-1406. psychology.clas.asu.edu/files/Bim-NelsonBehNeuro2003.pdf

2002:

Fitch, Roslyn Holly, & Bimonte, Heather A. (2002) Hormones, brain and behavior: putative biological contributions to cognitive sex differences. In: Biology, society and behavior: the development of sex differences in cognition (pages 55-91). Edited by: McGillicudy-DeLisi, A. and DeLisis, R., Ablex Publishing Westport, CT. 

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