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Recent Research Publications
2009:
Acosta J.I., Mayer L., Talboom J.S., Tsang C., Smith C., Enders C., Bimonte-Nelson H.A. Transitional versus surgical menopause in a rodent model: etiology of ovarian hormone loss impacts memory and the acetylcholine system, in press, Endocrinology.
Acosta J., Mayer L., Talboom J.S., Zay C.A., Scheldrup M., Castillo J., Demers L., Enders C., Bimonte-Nelson H.A. (2009) Premarin improves memory, prevents scopolamine-induced amnesia and increases number of basal forebrain choline acetyltransferase positive cells in middle-aged surgically menopausal rats, Hormones and Behavior, 55, 454–464.
Sas A., Bimonte-Nelson H.A., Smothers C., Woodward J., Tyor W. Interferon alpha causes neuronal dysfunction in encephalitis, in press, Journal of Neuroscience.
Lockrow J, Prakasam A, Huang P, Bimonte-Nelson H.A., Sambamurti K, Granholm AC. Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model, in press, Experimental Neurology.
Huentelman M.J., Stephan D.A., Talboom J.S., Reiman D.M., Gerber J.D., Barnes C.A., Alexander G.E., Reiman E.M., Bimonte-Nelson H.A. (2009) Peripheral delivery of a ROCK inhibitor improves learning and working memory, Behavioral Neuroscience, 123(1), 218-223.
2008:
Rao V.R., Sas A., Eugenin E., Siddappa N.B., Bimonte-Nelson H.A., Berman J., Ranga U., Tyor W.R., and Prasad V.R. (2008) Reduced leukocyte chemotaxis and chemokine induction by a subtype C HIV isolate in vitro correlates with reduction in neuropathology and cognitive dysfunction in SCID mouse HIV encephalitis, Journal of Neuroscience, 28(40):10010-10016.
Mclaughlin, K. Bimonte-Nelson, H., Neisewander, J., Conrad, C. (2008) Assessment of estradiol influence on spatial tasks and hippocampal CA1 spines: Evidence that prolonged ovariectomy compromises 17 beta-estradiol effectiveness in altering CA1 spines, Hormones and Behavior, 54(3), 386-395.
Thirumangalakudi L., Prakasam A., Zhang R., Bimonte-Nelson H.A., Sambamurti K., Kindy M. and Bhat N. (2008) High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice, Journal of Neurochemistry, 106(1), 475-485.
Granholm A-Ch., Bimonte-Nelson H.A., Moore A.B., Nelson M., Freeman L.R, Sambamurti K. (2008) Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat, Journal of Alzheimer’s Disease, 14(2),133-145.
Talboom J.S., Williams B.J., Baxley E., West, S., Bimonte-Nelson H.A. (2008) Higher levels of estradiol correlate with better spatial memory in surgically menopausal young and middle-aged rats, Neurobiology of Learning and Memory, 90, 155-163.
2007:
Bimonte-Nelson H.A., Granholm, A.C, Nelson, M.E., Moore, A.B. (2007) Patterns of neurotrophin protein levels in male and female rats from adulthood to senescence, Experimental Aging Research, 4, 13-26.
Sas A., Bimonte-Nelson H.A., Tyor WR. (2007) Increased Interferon-alpha in SCID mice with HIV encephalitis correlates with abnormal cognition, AIDS, 21, 2151-9.
French, K.L., Bimonte-Nelson, HA, Granholm, A-Ch. (2007) Galantamine effects on memory, spatial cue utilization and neurotrophic factors in aged female rats, Cell Transplantation, Special Aging Issue, 16, 197-205.
2006:
Williams BJ, Bimonte-Nelson HA and Granholm-Bentley AC. (2006) ERK-mediated NGF signaling in the rat septo-hippocampal pathway diminishes with age, Psychopharmacology, 88, 605-618.
French KL, Granholm AC, Moore AB, Nelson ME, Bimonte-Nelson HA (2006) Chronic nicotine mproves working and reference memory performance and reduces hippocampal NGF in aged female rats. Behavioral Brain Research, 169, 256-262.
Bimonte-Nelson, HA, Francis, K.R., Umphlet, C.D. and Granholm, A-C. (2006) Progesterone reverses the spatial memory enhancements of tonic and cyclic estrogen therapy in middle-aged female rats. European Journal of Neuroscience, 24, 229-242.
2004:
Hunter CL, Bimonte-Nelson HA, Nelson M, Eckman CB, Granholm AC. (2004) Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiology of Aging, 25, 873-84.
Bimonte-Nelson, H.A., Singleton, R.S., Williams, B.J., and Granholm, A.C. (2004) Ovarian hormones and cognition in the aged female rat: II. Progesterone supplementation reverses the cognitive enhancing effects of ovariectomy. Behavioral Neuroscience, 118, 707-714.
Bimonte-Nelson, H.A., Nelson, M.E, and Granholm, A.C. (2004) Progesterone counteracts estrogen- induced increases in neurotrophins in the aged female rat brain, Neuroreport, 15, 2659-2663.
2003:
Bimonte, H.A., Nelson, M.E., and Granholm, A.C. (2003) Age-related deficits as working memory load increases: relationships with growth factors. Neurobiology of Aging, 24, 37-48.
Bimonte, H.A., Hunter, C.L., Nelson, M.E., and Granholm, A-C. (2003) Frontal cortex BDNF levels correlate with working memory in an animal model of Down Syndrome. Behavioural Brain Research, 139, 47-57.
Hunter, C.L., Bimonte, H.A., and Granholm, A-C. (2003) Behavioral comparison of four and six month-old Ts65Dn mice: age-related impairments in working and reference memory. Behavioural Brain Research, 138, 121-131.
Hunter, C.L., Isacson, O., Nelson, M., Bimonte-Nelson, H.A., Seo., H., Lin, L., Ford, K., Kindy, M., and Granholm, A-C. (2003) Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down’s Syndrome. Neuroscience Research, 45(4):437-45.
Bimonte-Nelson, H.A., Singleton, R.S., Nelson, M.E., Eckman, C.B., Barber, J., Scott, T.Y., and Granholm, A.C. (2003) Testosterone, but not non-aromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats. Experimental Neurology, 81(2):301-12.
Bimonte-Nelson, H.A., Singleton, R.S., Hunter, C.L., Price, K.L., Moore, A., and Granholm, A.-C. (2003) Ovarian hormones and cognition in the aged female rat: I. Long-term, but not short-term, ovariectomy enhances spatial performance. Behavioral Neuroscience, 117, 1395-1406.

