Behavioral Neuroscience of Memory & Aging (Bimonte-Nelson)

Behavioral Neuroscience of Memory & Aging (Bimonte-Nelson)
Keywords
Keywords: learning; memory; behavior; estrogen; progesterone; hormone; menopause; maze
Lab Area
Behavioral Neuroscience and Comparative Psychology
Neuroscience
Lab Director
Heather Bimonte-Nelson, PhD
Actively Recruiting Undergraduate Researchers
No
Actively Recruiting Graduate Students
No

The research goals of our laboratory are to characterize the cognitive and brain changes that occur during aging, as well as to develop behavioral and pharmacological strategies to attenuate mnemonic and neurobiological age-related alterations. Towards this goal, one of our primary interests is to determine the roles that sex, hormones, and brain chemistry play in brain function and cognition in young versus aged subjects. Our interests incorporate these goals with relevance to Alzheimer’s disease-related variables, and non-pharmacological approaches to protecting the brain and cognition against age- and neurodegenerative- related changes.

One of our main aims is to determine the effects that hormone therapies used in women have on the brain and its function across the lifespan. For example, we have been studying the effects of Premarin, estradiol, and progestins on cognition and neurobiology in different types of menopause. We are also evaluating hormones in contraceptives for effects on the brain and cognition across the lifespan. Findings demonstrate that estrogen and progesterone can have divergent effects on memory and neurobiology in aging females, and that effects of ovarian hormone loss and replacement are impacted by many parameters including menopause history, temporal specifics, and age. 

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Your financial support may be considered a charitable contribution and all donations will be processed by the ASU Foundation for A New American University, a non-profit organization that exists to support Arizona State University (ASU). Your contribution to the Hormones, Menopause, and Memory Aging Lab and the Department of Psychology is greatly appreciated!

Bimonte-Nelson Lab Members

JOIN THE LAB!

Lab Director and Principal Investigator:  Heather Bimonte-Nelson, PhD

Dr. Bimonte-Nelson's undergraduate degree in Psychology was earned at Richard Stockton College, located near the beach in Pomona, NJ. To follow her interests in brain and behavior, she began her doctoral research under the mentorship of Dr. Victor Denenberg at the University of Connecticut where she focused upon sex differences in brain morphology and function, and how ovarian hormones affected the expression of sex differences in an activational and organizational fashion. The idea that gonadal hormones could have such a profound influence on the brain and behavior was intriguing to her and this area of work became her passion. After earning her PhD in 2000, she began a postdoctoral fellowship with Dr. Ann-Charlotte Granholm at the University of Colorado Health Sciences Center in Denver, and several months later, helped move the laboratory to the Medical University of South Carolina. In 2005, Dr. Bimonte-Nelson moved to ASU and founded the Bimonte-Nelson Memory and Aging Laboratory. When Dr. Bimonte-Nelson is not in the laboratory or teaching, she enjoys the beautiful Arizona atmosphere by spending time outdoors with husband, Matt, and their two teenage daughters. She also enjoys painting, music, concerts and writing short stories.

Doctoral Students

Veronica Pena, Doctoral Student. I received my BA in Psychology with a concentration in Neuroscience from Carleton College in 2012, and graduated from the University of Texas at Dallas with a M.S. in Applied Cognition and Neuroscience in 2016. Currently, I am a graduate student in the Behavioral Neuroscience PhD program. My research focuses on how menopause and hormone therapy impact healthy aging as well as neurodegenerative disease, specifically Alzheimer's disease behavior and pathology.

Victoria Bernaud, Doctoral Student. I am currently a fifth-year doctoral student in Dr. Heather Bimonte-Nelson’s Behavioral Neuroscience of Memory and Aging Laboratory. I received my MA in Spring 2020 while enrolled in the Behavioral Neuroscience PhD program in the Department of Psychology. My research explores the effects that surgical and hormonal alterations to the female reproductive system have on neurobiological and cognitive functioning during aging. I am also an ASU undergraduate alumna, Class of 2017, with concurrent Bachelor of Science degrees in Chemistry and Psychology.

Ashley Ruhland, Doctoral Student. I am in the second year of my doctoral study under the direction of Dr. Bimonte-Nelson in the Neuroscience of Aging and Memory laboratory. I received my BA in Spring of 2018 from Winona State University with majors in Psychology and Spanish, and minor in Criminal Justice. There, I had the opportunity to work on faculty research and received a WSU Undergraduate Research Grant to perform an independent study evaluating learning and memory following progesterone administration. I’m very looking forward to the further development of my research interests in the effects of ovarian hormones on cognition and neurobiology at ASU..

Taena Hanson, Doctoral Student. I am currently a second-year doctoral student in Dr. Heather Bimonte-Nelson's Behavioral Neuroscience of Memory and Aging Laboratory at ASU. Though originally from Boulder, Colorado, I graduated in the spring of 2020 from Creighton University with a Bachelor of Science in Neuroscience. My research interests include how various hormones interact with neurotransmitters in the brain and sex-based differences in drug activity.

Lab Manager

Steven Northup-Smith: I graduated with a BS from Grand Valley State University in 2016 with a double-major in Psychology and Biopsychology and a minor in Biology and earned my MBA in 2020. I moved to Phoenix from Grand Rapids, MI in the summer of 2016 and I have been Lab Manager of the Bimonte-Nelson lab since the fall of the same year.  Contact: snorthup@asu.edu

Undergraduate Research Assistants

Avantika Mitbander: Hello! I am an undergraduate sophomore earning a Bachelor of Science in Psychology and Neuroscience at The College of Liberal Arts and Sciences at ASU-Barrett the Honors College. I am also pursuing a minor in Spanish and a certificate in Cross-Sector Leadership. I have been a part of the lab since November 2020 and have continued to develop my knowledge of behavioral neuroscience since then. Additionally, I spend my free time empowering elementary students about diversity in science as a Co-Founder and Co-President of the Boundless Brilliance club at ASU. In the future, I hope to attend medical school and become an OBGYN so I can initiate positive change in the healthcare industry and continue to make an impact in my community.

Megan Nelson: Megan Nelson was born and raised in Gilbert, Arizona. She is a sophomore in Barrett, The Honors College, who is double-majoring in psychology and biological sciences with a concentration in neurobiology, physiology and behavior. She is looking forward to learning about memory and aging, and her goal is to earn a PhD in neuroscience in order to conduct behavioral neuroscience research in academia. 

Kieran Andrew: An Arizona native, I am currently a sophomore at Barrett the Honors College majoring in Psychology. My time in the lab began in the Fall of 2019. I enjoy learning about neuroscience and am grateful to get the opportunity to research topics such as how memory and aging affect the brain. I am excited to continue to work alongside my talented peers in the lab.

Sadaf Asadifar: I was born and raised in Iran, moved to Turkey at the age of 8 and moved to the US at the age of 10. I am currently a Sophomore at Barrett, The Honors College, pursuing a Bachelor of Science in Neuroscience and a minor in Global Health. I am incredibly grateful for the opportunity to work alongside the amazing graduate and undergraduate students working in the lab.

Valeria Olivares Attias: Hola! I am currently a first year student working towards a Bachelor of Science in Psychology. I was born in Santo Domingo, Dominican Republic and moved to Arizona five years ago. I strive to have a better understanding on an ideology I have which is that everything that is psychological is physiological. Additionally, I have been part of the lab since October 2020 and I look forward to furthering my education in this field.
 

Where are they now?

Joshua Talboom (2011, PhD) - currently a Post-doc at Translational Genomics Research Institute (TGEN)

B. Blair Braden (2012, PhD) - currently an Assistant Professor in the Department of Speech and Hearing Sciences at Arizona State University

Jazmin Acosta (2013, PhD & Post-doctoral fellow) - currently an Associate Medical Science Liaison, Medical Affairs at Kythera Biopharmaceuticals, Inc.

Elizabeth Engler-Chiurazzi (2013, PhD) - currently a Research Assistant Professor at the West Virginia University School of Medicine

Sarah Mennenga (2015, PhD) – currently pursuing a Post-Doc at New York University

Mari Willeman (2018, Post-doctoral fellow) - currently faculty at Glendale community college

Alesia Prakapenka (2018, PhD) - currently pursuing a Post-doc at Syracuse University

Stephanie Koebele (2019, PhD) - currently pursuing a Post-doc at Arizona State University

LABORATORY MANAGER: Alicia Quihuis - Currently a graduate student at the University of Southern California.

 

JOIN THE LAB!

Graduate Students
Prospective graduate students must meet the minimum qualifications for admittance in the Department of Psychology Graduate Program. Qualities of successful students include the following traits: highly motivated, dependable, organized, meeting challenges, working well with others as well as independently. Highly desirable are those who have had experience working in an animal research facility in the past. However, successful students have joined Dr. Bimonte-Nelson's laboratory without this experience. Please contact Dr. Bimonte-Nelson if you have any questions. Dr. Bimonte- Nelson's contact information is at the bottom of this page and graduate student contact information is available on this page (above).

Selected Publications

The list of publications below are just a sample of the work that's being done in our lab. For a complete list of Dr. Bimonte-Nelson's publications, please view her CV. 

* denotes graduate student or postdoc in our lab
^ denotes undergraduate student in our lab

2021

Bimonte-Nelson, H.A., Bernaud, V.E., Koebele, S.V. (2021). Menopause, hormone therapy and cognition: maximizing translation from preclinical research. Climacteric. PMID: 33977823

Bernaud, V.E., Hiroi, R., Poisson, M.L., Castaneda, A.J., Kirshner, Z.Z., Gibbs, R.B., Bimonte-Nelson, H.A. (2021). Age impacts the burden that reference memory imparts on an increasing working memory load and modifies relationships with cholinergic activity. Front Behav Neurosci, 15. PMID: 33643006

2020

Prakapenka, A.V.*, Quihuis, A.M.^, Carson, C.G.^, Patel, S.^, Bimonte-Nelson, H.A., Sirianni, R.W. (2020). Poly(lactic-co-glycolic acid) nanoparticle encapsulated 17β-estradiol improves spatial memory and increases uterine stimulation in middle-aged ovariectomized rats. Front Behav Neurosci, 14. PMID: 33424559

Koebele, S.V.*, Mennenga, S.E.*, Poisson, M.L.^, Hewitt, L.T.^, Patel, S.^, Mayer, L.P., Dyer, C.A., Bimonte-Nelson, H.A. (2020). Characterizing the effects of tonic 17β-estradiol administration on spatial learning and memory in the follicle-deplete middle-aged female rat. Horm Behav, 126. PMID: 32949557 

Prakapenka, A.V.*, Quihuis, A.M.^, Carson, C.G.^, Patel, S.^, Bimonte-Nelson, H.A., Sirianni, R.W. (2020). Encapsulated 17β-estradiol improves spatial memory and increases uterine stimulation in middle-aged ovariectomized rats. Front Behav Neurosci, 14. PMID: 33424559

Prakapenka, A.V.*, Peña, V.L.*, Strouse, I.^, Northup-Smith, S., Schrier, A.^, Ahmed, K.^, Bimonte-Nelson, H.A., Sirianni, R.W. (2020). Intranasal 17β-estradiol modulates spatial learning and memory in a rat model of surgical menopause. Pharmaceutics, 12(12). PMID: 33348722

2019

*Koebele, S.V., Nishimura, K.J., Bimonte-Nelson, H.A., Kemmou, S., Ortiz, J.B., Judd, J.M., Conrad, C.D. (2019). A long-term cyclic plus tonic regimen of 17β-estradiol improves the ability to handle a high spatial working memory load in ovariectomized middle-aged female rats. Hormones and Behavior, 118. PMID: 31862208

Holter, M.C., Hewitt, L.T., *Koebele, S.V., Judd, J.M., Xing, L., Bimonte-Nelson, H.A., Conrad, C.D., Araki, T., Neel, B,G., Snider, W.D., Newbern, J.M. (2019) The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning. PLoS Genet. 15(4). doi: 10.1371/journal.pgen.1008108. PMID: 31017896

 Goenaga, J., Powell, G.L., Leyrer-Jackson, J.M., Piña, J., Phan, S., *Prakapenka, A.V., *Koebele, S.V., Namba, M.D., McClure, E.A., Bimonte-Nelson, H.A., Gipson, C.D. (2019). N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking. Addict Bioldoi: 10.1111/adb.12711. PMID: 30734439

*Koebele S.V., ^Palmer J.M., ^Hadder B., ^Melikian R., ^Fox C., ^Strouse I.M., DeNardo D.F., George C., Daunis E., Nimer A., Mayer L.P., Dyer C.A., Bimonte-Nelson H.A. (2019). Hysterectomy uniquely impacts spatial memory in a rat model: a role for the nonpregnant uterus in cognitive processes. Endocrinology. 160(1):1-19. doi: 10.1210/en.2018-00709. PMID: 30535329.

2018

*Prakapenka, Alesia V., and Heather A. Bimonte-Nelson (2018). Memory and Menopause: An Unsolved Puzzle. Aging 10: 2541-543. PMID: 30321139

Rajeth K., Bimonte-Nelson H.A., Ciavatta V., Haile W., Elmore K., Ward J., Maroun L., Tyor W.R. (2018). Reversing interferon-alpha neurotoxicity in a HIV-associated neurocognitive disorder mouse model. AIDS. 32:1403-11. doi: 10.1097/QAD.0000000000001836

Tyor W.R., Bimonte-Nelson H.A. (2018) A mouse model of HIV-associated neurocognitive disorders: a brain-behavior approach to discover disease mechanisms and novel treatments. J Neurovirol. 24(2): 180-4.  PMID: 28895064.

*Prakapenka A.V., *Hiroi R., Quihuis A.M., ^Carson C., ^Patel S., ^Berns-Leone C., ^Fox C., Sirianni R.W., Bimonte-Nelson H.A. (2018) Contrasting effects of individual versus combined estrogen and progestogen regimens as working memory load increases in middle-aged ovariectomized rats: one plus one does not equal two. Neurobiol. Aging. 64:1-14. doi: 10.1016/j.neurobiolaging.2017.11.015. PMID: 29316527.

*Willeman M.N., *Mennenga S.E., Siniard, A.L., Corneveaux, J., De Both M., ^Hewitt L.T., Tsang, C.W.S., Caselli J., +Braden B.B., Bimonte-Nelson H.A., Huentelman J. (2018). The PKC-ß selective inhibitor, Enzastaurin, impairs memory in middle-aged rats. PloS One. 13(6). doi: 10.1371/journal.pone.0198256. PMID: 29870545.

2017

*Koebele S.V., *Mennenga S.E., *Hiroi R., ^Quihuis A.M., ^Hewitt L.T., ^Poisson M.L., George C., Mayer L.P., Dyer C.A., Aiken L.S., Demers L.M., ^Carson C., Bimonte-Nelson H.A. (2017) Cognitive changes across the menopause transition: A longitudinal evaluation of the impact of age and ovarian status on spatial memory. Hormones and Behavior, 87, 96-114. PMID: 27793768.

*Braden, B.B., Andrews, M.G., *Acosta, J.I., *Mennenga, S.E., Lavery, C., & Bimonte-Nelson, H.A. (2017). A comparison of progestins within three classes: differential effects on learning and memory in the aging surgically menopausal rat. Behavioral Brain Research, 322, 258-268.

*Koebele S.V., *Mennenga S.E., ^Patel, S., *Hiroi R., Hewitt, L.T., ^Quihuis A.M., Mayer L.P., Dyer C.A., Demers L.M., Bimonte-Nelson H.A. (2017). Menopause and the aging brain: Evaluating relationships between circulating ovarian hormone levels and choline acetyltransferase-containing neurons in the basal forebrain. Experimental Gerontology, 94, 111-112.

*Koebele, S.V. & Bimonte-Nelson, H.A. (2017). The endocrine-brain-aging triad where many paths meet: Female reproductive hormone changes at midlife and their influence on circuits important for learning and memory. Experimental Gerontology, 94, 14–23.

*Prakapenka, A.V., Bimonte-Nelson, H.A., & Sirianni, R. (2017). Engineering poly(lactic- co –glycolic acid) (PLGA) micro- and nano- carriers for controlled delivery of 17beta-estradiol. Annals of Biomedical Engineering, 45, 1697-1709.

 2016

*Koebele S.V., Bimonte-Nelson H.A. (2016) Modeling menopause: The utility of rodents in translational behavioral endocrinology research. Maturitas, 87, 5-17.

*Hiroi R., Carbone D.L., Zuloaga D.G., Bimonte-Nelson H.A., and Handa R.J. (2016) Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood. Neuroscience320, 43-56.

*Braden B.B., ^Andrews M.G., *Acosta JI, *Mennenga S.E., ^Lavery C., Bimonte-Nelson H.A. (2016) A comparison of progestins within three classes: Differential effects on learning and memory in the aging surgically menopausal rat. Behavioral Brain Research, 30, 258-268. PMID: 27368418.

 *Braden B.B., Dassel KB, Bimonte-Nelson H.A., O'Rourke H.P., Connor D.J., Moorhous S., Sabbagh M.N., Caselli R.J., Baxter L.C. (2016) Sex and post-menopause hormone therapy effects on hippocampal volume and verbal memory. Neuropsychology, Development, and Cognition (Section B: Aging, Neuropsychology, and Cognition), 4, 1-20. PMID: 27263667.

*Hiroi R., ^Weyrich G., *Koebele S.V., *Mennenga S.E., *Talboom J.S., ^Hewitt L.T., ^Lavery C.N., ^Mendoza P., ^Jordan A., Bimonte-Nelson HA. (2016) Benefits of hormone therapy estrogens depend on estrogen type: 17β-estradiol and conjugated equine estrogens have differential effects on cognitive, anxiety-like, and depressive-like behaviors and increase tryptophan hydroxylase-2 mRNA levels in dorsal raphe nucleus subregions. Frontiers in Neuroscience, 10, 510-517. PMID: 28008302.

2015

*Mennenga, S.E., ^Gerson J.E., Dunckley T., Bimonte-Nelson H.A. (2015) Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing. Physiology & Behavior, 138, 260-265. PMID: 25250831.

*Braden B.B., ^Kingston M.L., Koenig E.N., ^Lavery C.N., ^Tsang C.W., Bimonte-Nelson H.A. (2015) The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats. Frontiers in Aging Neuroscience 7:149. PubMed PMID: 26321945.

*Mennenga S.E., ^Gerson J.E., *Koebele S.V., ^Kingston M.L., ^Tsang C.W., *Engler-Chiurazzi E.B., Baxter L.C., Bimonte-Nelson H.A. (2015) Understanding the cognitive impact of the contraceptive estrogen Ethinyl Estradiol: tonic and cyclic administration impairs memory, and performance correlates with basal forebrain cholinergic system integrity. Psychoneuroendocrinology. 54:1-13. PubMed PMID: 25679306.

Prokai L., Nguyen V., Szarka S., Garg P., Sabnis G., Bimonte-Nelson H.A., McLaughlin K.J., *Talboom J.S., Conrad C.D., Shughrue P.J., Gould T.D., Brodie A., Merchenthaler I., Koulen P., Prokai-Tatrai K. (2015) The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders. Science Translational Medicine. 7(297):113. PubMed PMID: 26203081.

Wallace E., Kim do Y., Kim K.M., Chen S., *Braden B.B., Williams J., Jasso K., ^Garcia A., Rho J.M., Bimonte-Nelson H., Maganti R. (2015) Differential effects of duration of sleep fragmentation on spatial learning and synaptic plasticity in pubertal mice. Brain Research. 1615:116-28. PubMed PMID: 25957790.

*Koebele S.V., Bimonte-Nelson H.A. (2015) Trajectories and phenotypes with estrogen exposures across the lifespan: What does Goldilocks have to do with it? Hormones and Behavior. 74:86-104. PubMed PMID: 26122297.

2014

*Mennenga S.E., Baxter L.C., ^Grunfeld I.S., Brewer G.A., Aiken L.S., *Engler-Chiurazzi E.B., *Camp B.W., *Acosta J.I., *Braden B.B., ^Schaefer K.R., ^Gerson J.E., ^Lavery C.N., ^Tsang C.W., ^Hewitt L.T., ^Kingston M.L., *Koebele S.V., Patten K.J., Ball B.H., McBeath M.K. Bimonte-Nelson H.A. (2014) Navigating to new frontiers in behavioral neuroscience: traditional neuropsychological tests predict human performance on a rodent-inspired radial-arm maze. Frontiers in Behavioral Neuroscience8. PMID: 25249951.

*Mennenga S.E., *Koebele S.V., ^Mousa A.A., ^Alderete T.J., ^Tsang C.W., *Acosta J.I., *Camp B.W., Demers L.M., Bimonte-Nelson H.A. (2014) Pharmacological blockade of the aromatase enzyme, but not the androgen receptor, reverses androstenedione-induced cognitive impairments in young surgically menopausal rats. Steroids. PMID: 25159107.

*Talboom J.S., West S.G., *Engler-Chiurazzi E.B., Enders C.K., ^Crain I., Bimonte-Nelson H.A. (2014) Learning to remember: cognitive training-induced attenuation of age-related memory decline depends on sex and cognitive demand, and can transfer to untrained cognitive domains. Neurobiology of Aging, 35(12), 2791-2802. PMID: 25104561.

2013

*Acosta J., *Hiroi R., *Camp B., *Talboom J., Bimonte-Nelson H.A. (2013) An update on the cognitive impact of clinically-used hormone therapies in the female rat: models, mazes, and mechanisms, Brain Research, Special Issue on Window of Opportunity for Hormone Therapy, 1514: 18-39. PMID: 23333453.

*Mennenga S., Bimonte-Nelson H.A. (2013) Translational cognitive endocrinology: Designing rodent experiments with the goal to ultimately enhance cognitive health in women, Brain Research, Special Issue on Window of Opportunity for Hormone Therapy, 1514: 50-62. PMID: 23391594

Singh M., Simpkins J.W., Bimonte-Nelson H.A., Brinton R.D. (2013) Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer's disease. Brain Research, Special Issue on Window of Opportunity for Hormone Therapy, 1514:1-2. PMID: 25249951.

Rao V.R., Neogi U., *Talboom J.S., Padilla L., Rahman M., Fritz-French C., Gonzalez-Ramirez S., Verma A., Wood C., Ruprecht R.M., Ranga U., Azim T., Joska J., Eugenin E., Shet A., Bimonte-Nelson H.A., Tyor W.R., Prasad V.R. (2013) Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence. Retrovirology, 10:61. PMID: 23758766.

Lab News & Highlights!

Heather was awarded one of the university's most prestigious faculty honors, the designation as President's Professor! She is one of only 40 ASU professors to ever receive this award. As a recipient, she is recognized for her "enthusiasm and innovation in teaching, the ability to inspire original and creative work by students, mastery of subject matter and scholarly contributions."

Victoria Bernaud received the Sharon Manne Graduate Student Research Award! This award provides funds to PhD students who are conducting research in the fields of clinical and health psychology and behavioral neuroscience that aims to address mental and physical health issues. 

Haidyn Bulen received a Fulbright award to conduct research in Australia for three years

Stephanie Koebele won the Federation of Associations in Behavioral and Brain Sciences (FABBS) Doctoral Dissertation Research Excellence Award! More information can be found here.

Victoria Woner successfully defended her Master’s thesis entitled “Young Adult and Middle-age Rats Display Unique Working Memory Impairment and Differential Neurobiological Profiles Following Hysterectomy” on January 15th, 2020! 

Haidyn Bulen defended her honors thesis and received Top Honors Thesis in the Psychology Department!

Victoria Woner was awarded the Society for Neuroscience Trainee Professional Development Award (TPDA)! Article can be found here.

Veronica Pena successfully defended her Master’s thesis entitled “Progestogens Impact Cognition During the Transition to Menopause in the Rat: Dissociation of Progestogen- and Memory- Type” on September 19th, 2019!

Stephanie Koebele successfully defended her PhD on July 8th, 2019! Dr. Koebele's dissertation is entitled, "Variations in Menopause Etiology Affect Cognitive Outcomes: How Age, Menopause Type, and Exogenous Ovarian Hormone Exposures Across the Lifespan Impact the Trajectory of Brain Aging."

 Isabel Strouse defended her honors thesis and received the 2019 Barrett Award for Outstanding Research, which only two undergraduates in the Barrett Honors program receive each year! She was also awarded the Top Honors Thesis in the Psychology department.

Stephanie Koebele received the 2019 Faculty Women's Association Outstanding Graduate Student Award!

Alesia Prakapenka successfully defended her PhD on October 25th, 2018 and started her Postdoctoral Fellowship at Syracuse University with Dr. Donna Korol. Dr. Prakapenka's doctoral thesis is entitled: "Optimizing the Delivery of 17β-estradiol: Maximizing Beneficial Cognitive Effects While Minimizing Undesired Peripheral Stimulation in a Rat Model of Surgical Menopause

60 third grade students and 4 teachers from William T. Machan elementary school participated in the 2019 Brain Fair for Children with 10 volunteer instructors from the lab who helped.

Stephanie Koebele did a press release for her publication "Hysterectomy Uniquely Impacts Spatial Memory in a Rat Model: A Role for the Nonpregnant Uterus in Cognitive Processes." More information can be found here.

Haidyn Bulen presented research on sex differences in Alzheimer’s disease.  at the ASU-Banner Neuroscience Symposium, hosted by the ASU-Banner Neurodegenerative Disease Research Center. The symposium capped off the Banner-ASU Neuroscience Scholars Program, which is a paid, eight-week research training program available to undergraduate students nationwide.

AZBio named Heather Bimonte-Nelson the 2018 Michael A. Cusanovich Arizona Bioscience Educator of the Year for her commitment to developing the next generation of inquiring minds.

Justin Palmer won "Best Undergraduate Thesis" in the Psychology department for his thesis titled, “An Evaluation of the Cognitive Effects of a Short-Term and a Long-Term Ovarian Hormone Deprivation in a Transgenic Mouse Model of Alzheimer’s Disease: Addressing the Critical Window."

The Bimonte-Nelson lab teamed up with Red Mountain High school for the second consecutive year to teach students about the brain at the 2018 Red Mountain STEM day.

Justin Palmer won the 2017-2018 Federation of Associations in Behavioral and Brain Sciences Undergraduate Research Excellence Award! This award acknowledges and honors undergraduate student investigators who have conducted research of superior quality and with broader societal impact.

75 third grade students and 4 teachers from Creighton elementary school participated in the 2018 Brain Fair for Children with 11 volunteer instructors from the lab who helped.

Alesia Prakapenka won the 2018 Outstanding Graduate Student Award from the Faculty Women’s Association!

Isabel Strouse and Justin Palmer won 1st and 2nd place for their posters at the 2018 Arizona Psychology Undergraduate Research Conference (AZPURC)!

55 third grade students and 4 teachers from Creighton elementary school participated in the 2017 Brain Fair for Children with 11 volunteer instructors from the lab who helped.

About sixty 4th and 5th grade students and two teachers from Kyrene's Monte Vista elementary school participated in the 15 March 2016 Brain Fair organized by Dr. Sheri Hiroi with seven volunteer instructors from the lab who helped. For more pics and info about our Brain Fairs, click here! (posted 5/9/16).

Stephanie Koebele just won a competitive scholarship to attend the August 2016 Practical Workshop in Confocal Microscopy and Stereology in Chicago. The purpose of this intensive, week-long workshop is for researchers in biomedical science to learn new cell quantification microscopy techniques including a comprehensive overview in the theory and practice of modern histological preparation and microscopic analysis. Notes Dr. Bimonte-Nelson, “we’re so proud of Stephanie’s accomplishment in winning this award and look forward to her conducting her own workshop to teach us these new skills and techniques!” (posted 4/27/16).

Explore the new book which provides a laboratory roadmap for testing cognition in rodents, edited by Heather with stellar contributions from leaders in the field including personal accounts and scientific perspectives of their key discoveries: The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition

  

Doctoral student Stephanie Koebele wins Young Investigator Award at the 10th European Congress on Menopause and Andropause (EMAS). Read more about Stephanie's fabulous achievement!

 

Read about Brain Fairs for Children, organized by the Bimonte-Nelson lab and attended by hundreds of happy kids!

Doctoral student and lab member Sarah Mennenga earned the Psychology Department scholar award and successfully defended her PhD in 2015. She recently started her Postdoctoral Fellowship at NYU.

Bimonte-Nelson Lab graduate student Alesia Prakapenka won an NSF award co-mentored by Dr. Heather Bimonte-Nelson and Dr. Rachael Sirianni at Barrow Neurological Institute, entitled "Development of targeted delivery of estrogen to examine its effect on cognitive function." 

Bimonte-Nelson Lab, Washington DC, Society for Neuroscience 2014 (above)

Bimonte-Nelson Lab Dinner, Society for Neuroscience 2013 in San Diego (left).

Nobel Laureate Dr. Eric Kandel visiting the lab at ASU in 2012.

Contact Us

To apply, please email principal investigator and Professor Dr. Bimonte-Nelson and contact laboratory manager Steven Northup-Smith for the Undergraduate Research Assistant application.

Research Opportunity Description

Research Technicians
Dr. Bimonte-Nelson expects the same traits from her research technicians as she does for her graduate students (see above). Potential applicants must also be hardworking and dependable with a BA or BS in psychology or biology. Animal handling experience is a plus as well as laboratory work, management and maintenance experience. Dr. Bimonte-Nelson asks that applicants be dedicated to this position for at least 4 years (the duration of a grant). 

Undergraduate Research Volunteers
We are interested in accepting undergraduates into our laboratory team who have interests in studying the neurobiological and cognitive effects of hormones and aging.  Students who are more likely to be considered are Psychology majors, focusing on pursuing a career in neural behavioral research. The majority of the work will involve behavioral testing on our various maze tasks. Other duties that will be required will involve assistance/participation in experimental procedures, surgeries, and laboratory data management.

Requirements for undergraduate researchers:

Highly responsible
Highly motivated and enthusiastic
Punctual and organized
Can work independently as well as within a group
Willing to run behavioral procedures in the morning to late afternoon
Willing and able to work with the rodent model, and to assist with surgery
A year minimum before graduation (training takes time)
Morning availability

Note: Undergraduates work on a volunteer basis or through the Honors College; some are eligible to earn competitive funding through the College of Liberal Arts and Sciences SOLUR program.